Endocrine Abstracts

Background: Sheehan’s syndrome or postpartum pituitary necrosis though rare, is still remains one of the commonest causes of hypopituitarism in the developing parts of world like Indian subcontinent. The clinical presentation is often variable and frequently accompanied by hypogonadism which leads to low bone density due to loss of bone protective effect of oestrogen.Aims: To find out the bone mineral density and the quality of life (QoL) i...

Introduction: Thyroid cancer is the most common malignant endocrine tumour and represents 1% of all malignancies. Cancer Research UK in 2015 reported 3528 new cases and 382 deaths with annual incidence of 5.1 and 1.9 per 100,000 women and men respectively. The incidence is increasing globally, mostly due to papillary thyroid cancer.Ultrasound is the preferred examination with recommended U1-U5 grading system +/- fine-needle aspiration cytology (FNAC)...

The guidelines for management of prolactinomas (PRLoma) during pregnancy are mostly based on retrospective evidence or expert opinion. We conducted a survey of four Canadian provinces (NS, NB, PEI and BC) to assess the current trends in management of PRLoma during pregnancy. A case-based electronic questionnaire was sent to all practicing endocrinologists, with 3 cases of varying severity ranging from a micro PRLoma to a large macroPRLoma compressing the optic chiasm. A total ...

Background: All children with Growth Hormone Deficiency (GHD) should have a Magnetic Resonance Imaging (MRI) scan performed as standard (GH Research Society, 2000).Aims: To determine whether all patients diagnosed with GHD as determined by stimulation testing had an MRI scan performed; and to examine the relationship between the results of endocrine investigations and MRI scans.Methods: Retrospective review of all children who had ...

Attenuated glucoprivic feeding responses are a feature of hypoglycaemic unawareness in insulin-treated diabetes. Glucose alters the activity of hypothalamic neurones involved in regulating appetite. Arcuate nucleus (ARC) Neuropeptide Y (NPY) releasing neurones stimulate feeding. The identification of glucose-sensitive NPY releasing hypothalamic neurones suggests a strong role for these neurones in mediating changes in appetite induced by alterations of glucose. To gain a bette...

Background: The Scottish Genital Anomaly Network(SGAN) is a national managed clinical network that provides care to patients with a suspected disorder of sex development(DSD). Factors that influence the decision to perform a karyotype in suspected DSD are unclear.Aim: To explore the SGAN register to study the factors that influence the decision to perform a karyotype. Variables examined included centre of presentation, examination findings and associated...

Bariatric surgery in people with morbid obesity results in effective long-term weight loss, and resolution or reduction in the severity of several co-morbid conditions. The majority of obese people with type 2 diabetes who undergo bariatric surgery, achieve remission of their diabetes or a significant reduction of their glucose lowering therapy in the long-term. We conducted a retrospective observational study to assess changes in body weight and glycaemic control in obese typ...

Hypoglycaemia and hypoglycaemia unawareness severely limit the optimal management of diabetes mellitus and cause recurrent morbidity and even mortality in intensively controlled patients. Altered hypothalamic glucose sensing has been implicated in the development of defective counter regulatory responses to insulin induced hypoglycaemia and hypoglycaemic unawareness. This change in hypothalamic glucose sensing has been attributed, at least in part, to an increase in glucokinas...

Case: We are describing a case of 57-year-old gentleman who initially presented to gastroenterology clinic with iron deficiency anaemia (Hb – 11, Ferritin – 5) and 2 stone weight loss. An OGD was performed which demonstrated a polypoidal tumor in the distal body of stomach. Histology proved it to be carcinoid tumor. Staging CT thorax/abdomen showed marked gastric rugal thickening involving the fundus and body of the stomach with no extra mural spread, nodal disease o...

Introduction: Testosterone treatment can improve symptoms in hypogonadal men with depression. It is also known to induce aggressive behaviour hypomania and even mania. When patients with bipolar disorder and hypogonadism present with manic symptoms it is particularly difficult to decide whether testosterone should be discontinued or not during manic phase of the illness.Case: A 39 years old Caucasian man was diagnosed with isolated hypogonadotropic hypog...